Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions

• প্রধান লেখক: Guiomar Rodríguez-Periñán (Author), Ana de la Encarnación (Author), Fermín Moreno (Author), Adolfo López de Munain (Author), Ana Martínez (Author), Ángeles Martín-Requero (Author), Carolina Alquézar (Author), Fernando Bartolomé (Author)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2023-02-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Loss-of-function (LOF) mutations in <i>GRN</i> gene, which encodes progranulin (PGRN), cause frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). FTLD-TDP is one of the most common forms of early onset dementia, but its pathogenesis is not fully understood. Mitochondrial...