CSF1R inhibition reprograms tumor-associated macrophages to potentiate anti-PD-1 therapy efficacy against colorectal cancer

• Main Authors: Qi Lv (Author), Yishu Zhang (Author), Wen Gao (Author), Juan Wang (Author), Yaowen Hu (Author), Hongqiong Yang (Author), Ying Xie (Author), Yingshan Lv (Author), Heyuan Zhang (Author), Dapeng Wu (Author), Lihong Hu (Author), Junwei Wang (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PD-1 blockade therapy has made great breakthroughs in treatment of multiple solid tumors. However, patients with microsatellite-stable (MSS) colorectal cancer (CRC) respond poorly to anti-PD-1 immunotherapy. Although CRC patients with microstatellite instability (MSI) or microsatellite instability-h...