SMAD3 Host and Tumor Profiling to Identify Locally Advanced Rectal Cancer Patients at High Risk of Poor Response to Neoadjuvant Chemoradiotherapy

• Main Authors: Elena De Mattia (Author), Vincenzo Canzonieri (Author), Jerry Polesel (Author), Silvia Mezzalira (Author), Chiara Dalle Fratte (Author), Eva Dreussi (Author), Rossana Roncato (Author), Alessia Bignucolo (Author), Roberto Innocente (Author), Claudio Belluco (Author), Salvatore Pucciarelli (Author), Antonino De Paoli (Author), Elisa Palazzari (Author), Giuseppe Toffoli (Author), Erika Cecchin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Identifying patients at risk of poor response to neoadjuvant chemoradiotherapy (nCRT) is an emerging clinical need in locally advanced rectal cancer (LARC). SMAD3 is a key player in the chemoradio-resistance phenotype and its expression is both constitutive and locally induced. The aim was to invest...