An Adaptive Biosystems Engineering Approach towards Modeling the Soluble-to-Insoluble Phase Transition of Clofazimine

• Glavni autori: Andrew R. Willmer (Autor), Steven Dunne (Autor), Rosemary Swanson (Autor), Deepak Almeida (Autor), Nicole C. Ammerman (Autor), Kathleen A. Stringer (Autor), Edmund V. Capparelli (Autor), Gus R. Rosania (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2021-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Clofazimine (CFZ) is a weakly basic, small-molecule antibiotic used for the treatment of mycobacterial infections including leprosy and multidrug-resistant tuberculosis. Upon prolonged oral administration, CFZ precipitates and accumulates within macrophages throughout the host. To model the pharmaco...