An Adaptive Biosystems Engineering Approach towards Modeling the Soluble-to-Insoluble Phase Transition of Clofazimine

• প্রধান লেখক: Andrew R. Willmer (লেখক), Steven Dunne (লেখক), Rosemary Swanson (লেখক), Deepak Almeida (লেখক), Nicole C. Ammerman (লেখক), Kathleen A. Stringer (লেখক), Edmund V. Capparelli (লেখক), Gus R. Rosania (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2021-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Clofazimine (CFZ) is a weakly basic, small-molecule antibiotic used for the treatment of mycobacterial infections including leprosy and multidrug-resistant tuberculosis. Upon prolonged oral administration, CFZ precipitates and accumulates within macrophages throughout the host. To model the pharmaco...