An Adaptive Biosystems Engineering Approach towards Modeling the Soluble-to-Insoluble Phase Transition of Clofazimine

• Main Authors: Andrew R. Willmer (Author), Steven Dunne (Author), Rosemary Swanson (Author), Deepak Almeida (Author), Nicole C. Ammerman (Author), Kathleen A. Stringer (Author), Edmund V. Capparelli (Author), Gus R. Rosania (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clofazimine (CFZ) is a weakly basic, small-molecule antibiotic used for the treatment of mycobacterial infections including leprosy and multidrug-resistant tuberculosis. Upon prolonged oral administration, CFZ precipitates and accumulates within macrophages throughout the host. To model the pharmaco...