Preparation and Evaluation of Amino Acid Conjugates of Celecoxib as Prodrugs to Improve the Pharmacokinetic and Therapeutic Properties of Celecoxib

• Những tác giả chính: Yonghyun Lee (Tác giả), Jungyun Kim (Tác giả), Wooseong Kim (Tác giả), In-Soo Yoon (Tác giả), Yunjin Jung (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2020-10-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Although celecoxib is quite effective in the management of inflammation-related diseases, especially arthritis, its use is limited by concerns including low bioavailability (BA), non-linear pharmacokinetic (PK) profile, and peak concentration-related toxicity. To overcome these issues, we designed a...