Preparation and Evaluation of Amino Acid Conjugates of Celecoxib as Prodrugs to Improve the Pharmacokinetic and Therapeutic Properties of Celecoxib

Although celecoxib is quite effective in the management of inflammation-related diseases, especially arthritis, its use is limited by concerns including low bioavailability (BA), non-linear pharmacokinetic (PK) profile, and peak concentration-related toxicity. To overcome these issues, we designed a...

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Главные авторы: Yonghyun Lee (Автор), Jungyun Kim (Автор), Wooseong Kim (Автор), In-Soo Yoon (Автор), Yunjin Jung (Автор)
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Опубликовано: MDPI AG, 2020-10-01T00:00:00Z.
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