A de novo Non-sense Nuclear Factor I B Mutation (p.Tyr290*) Is Responsible for Brain Malformation and Lung Lobulation Defects

• Główni autorzy: Hao Huang (Autor), Jieyuan Jin (Autor), Liping Wu (Autor), Huifen Wu (Autor), Huichun Pi (Autor), Yi Dong (Autor), Rong Xiang (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

BackgroundNuclear factor I B (NFIB) plays an important role in regulating the transcription of multiple biological processes. Mutations in NFIB cause intellectual disability and macrocephaly. However, studies on abnormal brain and lung development caused by NFIB mutations are lacking.MethodsIn the p...