Synthesis and Biological Evaluation of a Radiolabeled PET (Positron Emission Tomography) Probe for Visualization of In Vivo α-Fucosidase Expression

• Hauptverfasser: Jonathan Cotton (Verfasst von), Chris Marc Goehring (Verfasst von), Anna Kuehn (Verfasst von), Andreas Maurer (Verfasst von), Kerstin Fuchs (Verfasst von), Bernd J. Pichler (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2021-07-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

The acidic hydrolase α-fucosidase (AF) is a biomarker for maladies such as cancer and inflammation. The most advanced probes for α-fucosidase are unfortunately constrained to ex vivo or in vitro applications. The in vivo detection and quantification of AF using positron emission tomography would all...