Abnormally high plasma concentrations of M-4, the active metabolite of edoxaban, at the onset of acute kidney injury in a patient receiving rifampin and clarithromycin: a case report

• Main Authors: Junichi Nakagawa (Author), Keinosuke Ishido (Author), Norihisa Kimura (Author), Hayato Nagase (Author), Yusuke Wakasa (Author), Satoshi Yokoyama (Author), Kayo Ueno (Author), Kenichi Hakamada (Author), Takenori Niioka (Author)
• Format: Book
• Published: BMC, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Edoxaban, the only factor Xa inhibitor with active metabolites, is metabolized by carboxylesterase-1 to its main active metabolite, M-4, which is a substrate of organic anion transporting polypeptide 1B1 (OATP1B1) and is excreted in bile and urine. Because the area under the plas...