Presence of benznidazole conjugated metabolites in urine identified by β-glucuronidase treatment

• Autores principales: María Elena Marson (Autor), Facundo García Bournissen (Autor), Jaime Altcheh (Autor), Guillermo Moscatelli (Autor), Samantha Moroni (Autor), Guido Enrique Mastrantonio (Autor)
• Formato: Libro
• Publicado: Universidade de São Paulo, 2020-03-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Chagas disease is a serious public health problem in Latin America and, due to migration, in other non-endemic regions. Benznidazole (BNZ) is first choice drug in pediatric therapeutics. However, little is known regarding its metabolism in humans. The aim of the study was to isolate and identify pro...