Persulfidation of Human Cystathionine <i>γ</i>-Lyase Inhibits Its Activity: A Negative Feedback Regulation Mechanism for H₂S Production

• Main Authors: Guanya Jia (Author), Heng Li (Author), Haisheng Gan (Author), Jun Wang (Author), Zhilong Zhu (Author), Yanxiong Wang (Author), Yongyi Ye (Author), Xiaoya Shang (Author), Weining Niu (Author)
• Format: Book
• Published: MDPI AG, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cystathionine γ-lyase (CSE) is the second enzyme in the trans-sulfuration pathway that converts cystathionine to cysteine. It is also one of three major enzymes responsible for the biosynthesis of hydrogen sulfide (H₂S). CSE is believed to be the major source of endogenous H&l...