Clinical Ocular Exposure Extrapolation for a Complex Ophthalmic Suspension Using Physiologically Based Pharmacokinetic Modeling and Simulation

• Principais autores: Maxime Le Merdy (Autor), Jessica Spires (Autor), Ming-Liang Tan (Autor), Liang Zhao (Autor), Viera Lukacova (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2024-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The development of generic ophthalmic drug products with complex formulations is challenging due to the complexity of the ocular system and a lack of sensitive testing to evaluate the interplay of its physiology with ophthalmic drugs. New methods are needed to facilitate the development of ophthalmi...