Clinical Ocular Exposure Extrapolation for a Complex Ophthalmic Suspension Using Physiologically Based Pharmacokinetic Modeling and Simulation

• मुख्य लेखकों: Maxime Le Merdy (लेखक), Jessica Spires (लेखक), Ming-Liang Tan (लेखक), Liang Zhao (लेखक), Viera Lukacova (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2024-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The development of generic ophthalmic drug products with complex formulations is challenging due to the complexity of the ocular system and a lack of sensitive testing to evaluate the interplay of its physiology with ophthalmic drugs. New methods are needed to facilitate the development of ophthalmi...