Biotransformation of Modified Benzylisoquinoline Alkaloids: Boldine and Berberine and In Silico Molecular Docking Studies of Metabolites on Telomerase and Human Protein Tyrosine Phosphatase 1B

• Main Authors: Duaa Eliwa (Author), Abdel-Rahim S. Ibrahim (Author), Amal Kabbash (Author), Mona El-Aasr (Author), Michał Tomczyk (Author), Yousef A. Bin Jardan (Author), Gaber El-Saber Batiha (Author), Amany E. Ragab (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Natural nitrogen heterocycles biotransformation has been extensively used to prepare synthetic drugs and explore the fate of therapeutic agents inside the body. Herein, the ability of filamentous fungi to biotransform boldine and berberine was investigated. Docking simulation studies of boldine, ber...