LAMP-2 absence interferes with plasma membrane repair and decreases T. cruzi host cell invasion.

• Main Authors: Natália Fernanda Couto (Author), Dina Pedersane (Author), Luisa Rezende (Author), Patrícia P Dias (Author), Tayanne L Corbani (Author), Lívia C Bentini (Author), Anny C S Oliveira (Author), Ludmila F Kelles (Author), Thiago Castro-Gomes (Author), Luciana O Andrade (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma cruzi enters host cells by subverting the mechanism of cell membrane repair. In this process, the parasite induces small injuries in the host cell membrane leading to calcium entry and lysosomal exocytosis, which are followed by compensatory endocytosis events that drive parasites into h...