The lysosomal LAMTOR / Ragulator complex is essential for nutrient homeostasis in brown adipose tissue

• Main Authors: Gudrun Liebscher (Author), Nemanja Vujic (Author), Renate Schreiber (Author), Markus Heine (Author), Caroline Krebiehl (Author), Madalina Duta-Mare (Author), Giorgia Lamberti (Author), Cedric H. de Smet (Author), Michael W. Hess (Author), Thomas O. Eichmann (Author), Sarah Hölzl (Author), Ludger Scheja (Author), Joerg Heeren (Author), Dagmar Kratky (Author), Lukas A. Huber (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: In brown adipose tissue (iBAT), the balance between lipid/glucose uptake and lipolysis is tightly regulated by insulin signaling. Downstream of the insulin receptor, PDK1 and mTORC2 phosphorylate AKT, which activates glucose uptake and lysosomal mTORC1 signaling. The latter requires the l...