The lysosomal LAMTOR / Ragulator complex is essential for nutrient homeostasis in brown adipose tissue

• Үндсэн зохиолчид: Gudrun Liebscher (Зохиогч), Nemanja Vujic (Зохиогч), Renate Schreiber (Зохиогч), Markus Heine (Зохиогч), Caroline Krebiehl (Зохиогч), Madalina Duta-Mare (Зохиогч), Giorgia Lamberti (Зохиогч), Cedric H. de Smet (Зохиогч), Michael W. Hess (Зохиогч), Thomas O. Eichmann (Зохиогч), Sarah Hölzl (Зохиогч), Ludger Scheja (Зохиогч), Joerg Heeren (Зохиогч), Dagmar Kratky (Зохиогч), Lukas A. Huber (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2023-05-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Objective: In brown adipose tissue (iBAT), the balance between lipid/glucose uptake and lipolysis is tightly regulated by insulin signaling. Downstream of the insulin receptor, PDK1 and mTORC2 phosphorylate AKT, which activates glucose uptake and lysosomal mTORC1 signaling. The latter requires the l...