Smads as therapeutic targets for chronic kidney disease
Renal fibrosis is a hallmark of chronic kidney disease (CKD). It is generally thought that transforming growth factor-β1 (TGF-β1) is a key mediator of fibrosis and mediates renal scarring positively by Smad2 and Smad3, but negatively by Smad7. Our recent studies found that in CKD, TGF-β1 is not a so...
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The Korean Society of Nephrology,
2012-03-01T00:00:00Z.
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