Retinal Delivery of the Protein Kinase C-β Inhibitor Ruboxistaurin Using Non-Invasive Nanoparticles of Polyamidoamine Dendrimers

• Main Authors: Rehab A. Alshammari (Author), Fadilah S. Aleanizy (Author), Amal Aldarwesh (Author), Fulwah Y. Alqahtani (Author), Wael A. Mahdi (Author), Bushra Alquadeib (Author), Qamraa H. Alqahtani (Author), Nazrul Haq (Author), Faiyaz Shakeel (Author), Hosam G. Abdelhady (Author), Ibrahim A. Alsarra (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ruboxistaurin (RBX) is an anti-vascular endothelial growth factor (anti-VEGF) agent that is used in the treatment of diabetic retinopathy and is mainly given intravitreally. To provide a safe and effective method for RBX administration, this study was designed to develop RBX nanoparticles using poly...