APP-CD74 axis mediates endothelial cell-macrophage communication to promote kidney injury and fibrosis

• Ngā kaituhi matua: Bin Liu (Author), Faping Li (Author), Yuxiong Wang (Author), Xin Gao (Author), Yunkuo Li (Author), Yishu Wang (Author), Honglan Zhou (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

BackgroundKidney injuries often carry a grim prognosis, marked by fibrosis development, renal function loss, and macrophage involvement. Despite extensive research on macrophage polarization and its effects on other cells, like fibroblasts, limited attention has been paid to the influence of non-imm...