Na/H Exchange Regulatory Factor 1 Deficient Mice Show Evidence of Oxidative Stress and Altered Cisplatin Pharmacokinetics

• Main Authors: Adrienne M. Bushau-Sprinkle (Author), Michelle T. Barati (Author), Yuxuan Zheng (Author), Walter H. Watson (Author), Kenneth B. Gagnon (Author), Syed Jalal Khundmiri (Author), Kathleen T. Kitterman (Author), Barbara J. Clark (Author), Leah J. Siskind (Author), Mark A. Doll (Author), Michael E. Brier (Author), Susan Coventry (Author), Eleanor D. Lederer (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

(1) Background: One third of patients who receive cisplatin develop an acute kidney injury. We previously demonstrated the Na/H Exchange Regulatory Factor 1 (NHERF1) loss resulted in increased kidney enzyme activity of the pentose phosphate pathway and was associated with more severe cisplatin nephr...