Benzoic Acid Derivatives as Prodrugs for the Treatment of Tuberculosis

• Main Authors: João P. Pais (Author), Marta Magalhães (Author), Olha Antoniuk (Author), Ivete Barbosa (Author), Raquel Freire (Author), David Pires (Author), Emília Valente (Author), Bernard Testa (Author), Elsa Anes (Author), Luis Constantino (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One interesting approach to fight tuberculosis is the use of prodrugs that often have shown improved biological activities over drugs with poor absorption or difficulty to cross membranes. Previous studies demonstrate that weak acids such as benzoic acid, present antimycobacterial activity. Moreover...