Cardiac protection induced by urocortin-2 enables the regulation of apoptosis and fibrosis after ischemia and reperfusion involving miR-29a modulation

• Main Authors: Isabel Mayoral-González (Author), Eva M. Calderón-Sánchez (Author), Isabel Galeano-Otero (Author), Marta Martín-Bórnez (Author), Encarnación Gutiérrez-Carretero (Author), María Fernández-Velasco (Author), Nieves Domenech (Author), María Generosa Crespo-Leiro (Author), Ana María Gómez (Author), Antonio Ordóñez-Fernández (Author), Abdelkrim Hmadcha (Author), Tarik Smani (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Urocortin-2 (Ucn-2) has demonstrated cardioprotective actions against myocardial ischemia-reperfusion (I/R) injuries. Herein, we explored the protective role of Ucn-2 through microRNAs (miRNAs) post-transcriptional regulation of apoptotic and pro-fibrotic genes. We determined that the intravenous ad...