RalB degradation by dihydroartemisinin induces autophagy and IFI16/caspase-1 inflammasome depression in the human laryngeal squamous cell carcinoma

• Main Authors: Xinli Shi (Author), Shenghao Li (Author), Li Wang (Author), Hui Li (Author), Zhen Li (Author), Weiyi Wang (Author), Jing Bai (Author), Yajing Sun (Author), Jianchun Li (Author), Xiaoming Li (Author)
• Format: Book
• Published: BMC, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Interferon-inducible 16 (IFI16)/caspase-1 inflammasome activates and secretes IL-1β. However, it is still unclear whether the IFI16 inflammasome is involved in human laryngeal squamous cell carcinoma. Autophagy directly removed inflammasome components and limited early IL-1β prod...