Sustained Immunoparalysis in Endotoxin-Tolerized Monocytic Cells

• Main Authors: Christina K. Weisheit (Author), Alexandra Klüners (Author), Lennart Wild (Author), Alexandra Casalter (Author), Stefanie Heilmann-Heimbach (Author), Sugirthan Sivalingam (Author), Jan L. Kleiner (Author), Stefan F. Ehrentraut (Author), Andreas Hoeft (Author), Stilla Frede (Author), Heidi Ehrentraut (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sepsis is associated with a strong inflammatory reaction triggering a complex and prolonged immune response. Septic patients have been shown to develop sustained immunosuppression due to a reduced responsiveness of leukocytes to pathogens. Changes in cellular metabolism of leukocytes have been linke...