Structure-based virtual screening for novel p38 MAPK inhibitors and a biological evaluation

• প্রধান লেখক: Qinwen Zheng (লেখক), Yumeng Zhu (লেখক), Aoxue Wang (লেখক), Panpan Yang (লেখক), Xin Wang (লেখক), Wen Shuai (লেখক), Liang Ouyang (লেখক), Guan Wang (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Compuscript Ltd, 2023-09-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Mitogen-activated protein kinases (MAPKs) are a group of serine-threonine protein kinases that can be activated by extracellular stimuli. MAPK14 (p38α) affects major disease processes, while inhibition of p38α has been shown to have potential therapeutic effects. Many inhibitors targeting p38α have...