Structure-based virtual screening for novel p38 MAPK inhibitors and a biological evaluation

• Main Authors: Qinwen Zheng (Author), Yumeng Zhu (Author), Aoxue Wang (Author), Panpan Yang (Author), Xin Wang (Author), Wen Shuai (Author), Liang Ouyang (Author), Guan Wang (Author)
• Format: Book
• Published: Compuscript Ltd, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitogen-activated protein kinases (MAPKs) are a group of serine-threonine protein kinases that can be activated by extracellular stimuli. MAPK14 (p38α) affects major disease processes, while inhibition of p38α has been shown to have potential therapeutic effects. Many inhibitors targeting p38α have...