C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways

• Main Authors: Yan CHEN (Author), Yang LIU (Author), Hao LI (Author), Risu HUNA (Author), Xiaohan TAN (Author), Ning LI (Author), Yiying ZHANG (Author), Xiaohui JIAO (Author), Mingyue LIU (Author)
• Format: Book
• Published: University of São Paulo, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Objective Abnormal complement activation is associated with periodontitis. W54011 is a novel non-peptide C5aR antagonist (C5aRA) that exhibits favorable anti-inflammatory effects in various inflammatory models. However, whether W54011 inhibits periodontitis has not yet been fully elucidated...