6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers

• Main Authors: Laura Braconi (Author), Gianluca Bartolucci (Author), Marialessandra Contino (Author), Niccolò Chiaramonte (Author), Roberta Giampietro (Author), Dina Manetti (Author), Maria Grazia Perrone (Author), Maria Novella Romanelli (Author), Nicola Antonio Colabufo (Author), Chiara Riganti (Author), Silvia Dei (Author), Elisabetta Teodori (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aiming to deepen the structure-activity relationships of the two P-glycoprotein (P-gp) modulators elacridar and tariquidar, a new series of amide and ester derivatives carrying a 6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline scaffold linked to different methoxy-substituted aryl moieties w...