Development of Atomoxetine-Loaded NLC In Situ Gel for Nose-to-Brain Delivery: Optimization, In Vitro, and Preclinical Evaluation

• Main Authors: Dibyalochan Mohanty (Author), Omar Awad Alsaidan (Author), Ameeduzzafar Zafar (Author), Trishala Dodle (Author), Jeetendra Kumar Gupta (Author), Mohd Yasir (Author), Anshuman Mohanty (Author), Mohammad Khalid (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study investigates the brain-targeted efficiency of atomoxetine (AXT)-loaded nanostructured lipid carrier (NLC)-laden thermosensitive in situ gel after intranasal administration. AXT-NLC was prepared by the melt emulsification ultrasonication method and optimized using the Box-Behnken de...