Multiseed liposomal drug delivery system using micelle gradient as driving force to improve amphiphilic drug retention and its anti-tumor efficacy

• Main Authors: Wenli Zhang (Author), Caibin Li (Author), Ya Jin (Author), Xinyue Liu (Author), Zhiyu Wang (Author), John P. Shaw (Author), Bruce C. Baguley (Author), Zimei Wu (Author), Jianping Liu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To improve drug retention in carriers for amphiphilic asulacrine (ASL), a novel active loading method using micelle gradient was developed to fabricate the ASL-loaded multiseed liposomes (ASL-ML). The empty ML were prepared by hydrating a thin film with empty micelles. Then the micelles in liposomal...