Sodium Tanshinone IIA Sulfonate Decreases Cigarette Smoke-Induced Inflammation and Oxidative Stress via Blocking the Activation of MAPK/HIF-1α Signaling Pathway

• Main Authors: Ruijuan Guan (Author), Jian Wang (Author), Ziying Li (Author), Mingjing Ding (Author), Defu Li (Author), Guihua Xu (Author), Tao Wang (Author), Yuqin Chen (Author), Qian Yang (Author), Zhen Long (Author), Zhou Cai (Author), Chenting Zhang (Author), Xue Liang (Author), Lian Dong (Author), Li Zhao (Author), Haiyun Zhang (Author), Dejun Sun (Author), Wenju Lu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aberrant activation of hypoxia-inducible factor (HIF)-1α is frequently encountered and promotes oxidative stress and inflammation in chronic obstructive pulmonary disease (COPD). The present study investigated whether sodium tanshinone IIA sulfonate (STS), a water-soluble derivative of tanshinone II...