Two-Step Targeted Drug Delivery via Proteinaceous Barnase-Barstar Interface and Doxorubicin-Loaded Nano-PLGA Outperforms One-Step Strategy for Targeted Delivery to HER2-Overexpressing Cells

• Main Authors: Elena N. Komedchikova (Author), Olga A. Kolesnikova (Author), Ekaterina D. Tereshina (Author), Polina A. Kotelnikova (Author), Anna S. Sogomonyan (Author), Alexey V. Stepanov (Author), Sergey M. Deyev (Author), Maxim P. Nikitin (Author), Victoria O. Shipunova (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nanoparticle-based chemotherapy is considered to be an effective approach to cancer diagnostics and therapy in modern biomedicine. However, efficient tumor targeting remains a great challenge due to the lack of specificity, selectivity, and high dosage of chemotherapeutic drugs required. A two-step...