Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1

• Main Authors: Shiming Jiang (Author), Tiffany A. Katz (Author), Jason P. Garee (Author), Francesco J. DeMayo (Author), Adrian V. Lee (Author), Steffi Oesterreich (Author)
• Format: Book
• Published: The Company of Biologists, 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Scaffold attachment factors SAFB1 and SAFB2 are multifunctional proteins that share >70% sequence similarity. SAFB1-knockout (SAFB1−/−) mice display a high degree of lethality, severe growth retardation, and infertility in male mice. To assess the in vivo role of SAFB2, and to identify unique fun...