Dithiocarbamates effectively inhibit the α-carbonic anhydrase from Neisseria gonorrhoeae

• Main Authors: Simone Giovannuzzi (Author), Nader S. Abutaleb (Author), Chad S. Hewitt (Author), Fabrizio Carta (Author), Alessio Nocentini (Author), Mohamed N. Seleem (Author), Daniel P. Flaherty (Author), Claudiu T. Supuran (Author)
• פורמט: ספר
• יצא לאור: Taylor & Francis Group, 2022-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Recently, inorganic anions and sulphonamides, two of the main classes of zinc-binding carbonic anhydrase inhibitors (CAIs), were investigated for inhibition of the α-class carbonic anhydrase (CA, EC 4.2.1.1) from Neisseria gonorrhoeae, NgCA. As an extension to our previous studies, we report that di...