Differences in cNOS/iNOS Activity during Resistance to Trypanosoma cruzi Infection in 5-Lipoxygenase Knockout Mice

• Main Authors: Carolina Panis (Author), Vanessa Jacob Victorino (Author), Vera Lúcia Hideko Tatakihara (Author), Rubens Cecchini (Author), Luiz Vicente Rizzo (Author), Lucy Megumi Yamauchi (Author), Sueli Fumie Yamada-Ogatta (Author), Marli Cardoso Martins-Pinge (Author), Phileno Pinge-Filho (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Infection with the protozoan Trypanosoma cruzi causes Chagas disease and consequently leads to severe inflammatory heart condition; however, the mechanisms driving this inflammatory response have not been completely elucidated. Nitric oxide (NO) is a key mediator of parasite killing in T. cruzi-infe...