Non-small-cell lung cancer: how to manage RET-positive disease

• Main Authors: Elisa Andrini (Author), Mirta Mosca (Author), Linda Galvani (Author), Francesca Sperandi (Author), Biagio Ricciuti (Author), Giulio Metro (Author), Giuseppe Lamberti (Author)
• Format: Book
• Published: BioExcel Publishing Ltd, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeted therapy has dramatically changed the history and outcomes of oncogene-addicted non-small-cell lung cancer (NSCLC). RET rearrangements are typically observed in about 1-2% of NSCLC, resulting in constitutive activation of downstream signalling pathways commonly involved in cell growth and su...