Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer

Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer

Objective: The mitochondrial pyruvate carrier (MPC) has emerged as a promising drug target for metabolic disorders, including non-alcoholic steatohepatitis and diabetes, metabolically dependent cancers and neurodegenerative diseases. A range of structurally diverse small molecule inhibitors have bee...

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Main Authors: Sotiria Tavoulari (Author), Tom J.J. Schirris (Author), Vasiliki Mavridou (Author), Chancievan Thangaratnarajah (Author), Martin S. King (Author), Daniel T.D. Jones (Author), Shujing Ding (Author), Ian M. Fearnley (Author), Edmund R.S. Kunji (Author)
Format: Book
Published: Elsevier, 2022-06-01T00:00:00Z.
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3rd Floor Main Library

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