Enhancing efficacy of gemcitabine in pancreatic patient-derived xenograft mouse models

• Main Authors: Andriana Inkoom (Author), Nkafu Ndemazie (Author), Kevin Affram (Author), Taylor Smith (Author), Xue Zhu (Author), Patrick Underwood (Author), Sunil Krishnan (Author), Edward Ofori (Author), Bo Han (Author), Jose Trevino (Author), Edward Agyare (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gemcitabine (Gem), a nucleoside analog, is a preferred choice of treatment for pancreatic cancer (PCa) and often used in combination therapy against wide range of solid tumors. It is known to be rapidly inactivated in blood by cytidine deaminase. The objective of the study was to improve the systemi...