MANF brakes TLR4 signaling by competitively binding S100A8 with S100A9 to regulate macrophage phenotypes in hepatic fibrosis

• Main Authors: Chao Hou (Author), Dong Wang (Author), Mingxia Zhao (Author), Petek Ballar (Author), Xinru Zhang (Author), Qiong Mei (Author), Wei Wang (Author), Xiang Li (Author), Qiang Sheng (Author), Jun Liu (Author), Chuansheng Wei (Author), Yujun Shen (Author), Yi Yang (Author), Peng Wang (Author), Juntang Shao (Author), Sa Xu (Author), Fuyan Wang (Author), Yang Sun (Author), Yuxian Shen (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mesencephalic astrocyte-derived neurotrophic factor (MANF) has been recently identified as a neurotrophic factor, but its role in hepatic fibrosis is unknown. Here, we found that MANF was upregulated in the fibrotic liver tissues of the patients with chronic liver diseases and of mice treated wi...