A Novel CC-Chemokine Receptor 3 Antagonist, Ki19003, Inhibits Airway Eosinophilia and Subepithelial/Peribronchial Fibrosis Induced by Repeated Antigen Challenge in Mice

• Main Authors: Masato Komai (Author), Hiroyuki Tanaka (Author), Koichi Nagao (Author), Masayuki Ishizaki (Author), Daisuke Kajiwara (Author), Toru Miura (Author), Hiroshi Ohashi (Author), Tomoko Haba (Author), Kazuki Kawakami (Author), Eiji Sawa (Author), Osamu Yoshie (Author), Naoki Inagaki (Author), Hiroichi Nagai (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CC-chemokine receptor 3 (CCR3) is a chemokine receptor for which major ligands, CC-chemokine ligand (CCL) 11, CCL24, and CCL26, are known to be involved in chemotaxis for eosinophils. In the present study, we evaluated the effect of a low molecular weight CCR3-receptor antagonist, Ki19003 (4-[[5-(2,...