Single-nucleotide polymorphism profiling by multimodal-targeted next-generation sequencing in methotrexate-resistant and -sensitive human osteosarcoma cell lines

• Main Authors: Chiara Casotti (Author), Claudia Maria Hattinger (Author), Maria Pia Patrizio (Author), Silvia Luppi (Author), Leonardo Fantoni (Author), Michela Pasello (Author), Katia Scotlandi (Author), Toni Ibrahim (Author), Massimo Serra (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Methotrexate (MTX) is one of the most important drugs included in the first-line protocols to treat high-grade osteosarcoma (HGOS). Although several polymorphisms have been reported to be associated with drug response or MTX-related toxicity in pharmacogenetic studies, their role in th...