Single-nucleotide polymorphism profiling by multimodal-targeted next-generation sequencing in methotrexate-resistant and -sensitive human osteosarcoma cell lines

• Hauptverfasser: Chiara Casotti (Verfasst von), Claudia Maria Hattinger (Verfasst von), Maria Pia Patrizio (Verfasst von), Silvia Luppi (Verfasst von), Leonardo Fantoni (Verfasst von), Michela Pasello (Verfasst von), Katia Scotlandi (Verfasst von), Toni Ibrahim (Verfasst von), Massimo Serra (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Schlagworte: article
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Introduction: Methotrexate (MTX) is one of the most important drugs included in the first-line protocols to treat high-grade osteosarcoma (HGOS). Although several polymorphisms have been reported to be associated with drug response or MTX-related toxicity in pharmacogenetic studies, their role in th...