Leptospira Interrogans induces fibrosis in the mouse kidney through Inos-dependent, TLR- and NLR-independent signaling pathways.

• Main Authors: Martine Fanton d'Andon (Author), Nathalie Quellard (Author), Béatrice Fernandez (Author), Gwenn Ratet (Author), Sonia Lacroix-Lamandé (Author), Alain Vandewalle (Author), Ivo G Boneca (Author), Jean-Michel Goujon (Author), Catherine Werts (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Leptospira (L.) interrogans are bacteria responsible for a worldwide reemerging zoonosis. Rodents carry L. interrogans asymptomatically in their kidneys and excrete bacteria in the urine, contaminating the environment. Humans get infected through skin contact and develop a mild or severe...