New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway.

• Главные авторы: Rosely Oliveira Godinho (Автор), Thiago eDuarte (Автор), Enio Setsuo Arakaki Pacini (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2015-03-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

G protein-coupled receptors (GPCR) linked to stimulatory G (Gs) proteins (GsPCR) mediate increases in intracellular cyclic AMP as consequence of activation of nine adenylyl cyclases (AC), which differ considerably in their cellular distribution and activation mechanisms. Once produced, cyclic AMP ma...