Model-Based Equivalent Dose Optimization to Develop New Donepezil Patch Formulation

• Main Authors: Woojin Jung (Author), Heeyoon Jung (Author), Ngoc-Anh Thi Vu (Author), Gwan-Young Kim (Author), Gyoung-Won Kim (Author), Jung-woo Chae (Author), Taeheon Kim (Author), Hwi-yeol Yun (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Donepezil patch was developed to replace the original oral formulation. To accurately describe the pharmacokinetics of donepezil and investigate compatible doses between two formulations, a population pharmacokinetic model for oral and transdermal patches was built based on a clinical study. Plasma...