Bioassay-guided fractionation of extracts from Codiaeum variegatum against Entamoeba histolytica discovers compounds that modify expression of ceramide biosynthesis related genes.

• Main Authors: Emmanuel Mfotie Njoya (Author), Christian Weber (Author), Nora Adriana Hernandez-Cuevas (Author), Chung-Chau Hon (Author), Yves Janin (Author), Melanie F G Kamini (Author), Paul F Moundipa (Author), Nancy Guillén (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leaves of Codiaeum variegatum ("garden croton") are used against bloody diarrhoea by local populations in Cameroon. This study aims to search for the active components from C. variegatum against Entamoeba histolytica, and thereby initiate the study of their mechanism of action. A bioassay-...