Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid.

• Main Authors: Patrik Castiglioni (Author), Mary-Anne Hartley (Author), Matteo Rossi (Author), Florence Prevel (Author), Chantal Desponds (Author), Daniel T Utzschneider (Author), Remzi-Onur Eren (Author), Haroun Zangger (Author), Livia Brunner (Author), Nicolas Collin (Author), Dietmar Zehn (Author), F Matthew Kuhlmann (Author), Stephen M Beverley (Author), Nicolas Fasel (Author), Catherine Ronet (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies have shown that a cytoplasmic virus called Leishmaniavirus (LRV) is present in some Leishmania species and acts as a potent innate immunogen, aggravating lesional inflammation and development in mice. In humans, the presence of LRV in Leishmania guyanensis and in L. braziliensis was s...