Structural and functional analysis of a platelet-activating lysophosphatidylcholine of Trypanosoma cruzi.

• Main Authors: Felipe Gazos-Lopes (Author), Mauricio M Oliveira (Author), Lucas V B Hoelz (Author), Danielle P Vieira (Author), Alexandre F Marques (Author), Ernesto S Nakayasu (Author), Marta T Gomes (Author), Nasim G Salloum (Author), Pedro G Pascutti (Author), Thaïs Souto-Padrón (Author), Robson Q Monteiro (Author), Angela H Lopes (Author), Igor C Almeida (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma cruzi is the causative agent of the life-threatening Chagas disease, in which increased platelet aggregation related to myocarditis is observed. Platelet-activating factor (PAF) is a potent intercellular lipid mediator and second messenger that exerts its activity through a PAF-specific...