Rhubarb Protect Against Tubulointerstitial Fibrosis by Inhibiting TGF-β/Smad Pathway and Improving Abnormal Metabolome in Chronic Kidney Disease

• Main Authors: Zhi-Hao Zhang (Author), Ming-Hua Li (Author), Dan Liu (Author), Hua Chen (Author), Dan-Qian Chen (Author), Ning-Hua Tan (Author), Shuang-Cheng Ma (Author), Ying-Yong Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tubulointerstitial fibrosis is the final common pathway for all kidney diseases leading to chronic kidney disease (CKD). TGF-β/Smad signaling pathway plays a key role in renal fibrosis. Previous studies have revealed that rhubarb extracts attenuated the increase of transforming growth factor-β 1 (TG...