Modulation of the kappa and mu opioid axis for the treatment of chronic pruritus: A review of basic science and clinical implicationsCapsule Summary

• Main Authors: Sarina Elmariah, MD, PhD (Author), Sarah Chisolm, MD (Author), Thomas Sciascia, MD (Author), Shawn G. Kwatra, MD (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Treating chronic pruritus is challenging for dermatologists due to the lack of therapeutic options. We review the effects of κ-opioid receptor (KOR) and μ-opioid receptor (MOR) in the modulation of itch, summarize evidence supporting the efficacy and safety of opioid receptor-targeting...