A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from disease.

• Main Authors: Suganya Selvarajah (Author), Nicole R Sexton (Author), Kristen M Kahle (Author), Rachel H Fong (Author), Kimberly-Anne Mattia (Author), Joy Gardner (Author), Kai Lu (Author), Nathan M Liss (Author), Beatriz Salvador (Author), David F Tucker (Author), Trevor Barnes (Author), Manu Mabila (Author), Xiangdong Zhou (Author), Giada Rossini (Author), Joseph B Rucker (Author), David Avram Sanders (Author), Andreas Suhrbier (Author), Vittorio Sambri (Author), Alain Michault (Author), Marcus O Muench (Author), Benjamin J Doranz (Author), Graham Simmons (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mosquito-borne alphavirus, chikungunya virus (CHIKV), has recently reemerged, producing the largest epidemic ever recorded for this virus, with up to 6.5 million cases of acute and chronic rheumatic disease. There are currently no licensed vaccines for CHIKV and current anti-inflammatory drug tr...