The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy

• Príomhchruthaitheoirí: Irene Pérez (Údar), Elena Campos-Pardos (Údar), Caridad Díaz (Údar), Santiago Uranga (Údar), Fadel Sayes (Údar), Francisca Vicente (Údar), Nacho Aguiló (Údar), Roland Brosch (Údar), Carlos Martín (Údar), Jesús Gonzalo-Asensio (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Elsevier, 2022-03-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Cyclic (di)nucleotides act as universal second messengers endogenously produced by several pathogens. Specifically, the roles of c-di-AMP in Mycobacterium tuberculosis immunity and virulence have been largely explored, although its contribution to the safety and efficacy of live tuberculosis vaccine...