The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy

• Main Authors: Irene Pérez (Author), Elena Campos-Pardos (Author), Caridad Díaz (Author), Santiago Uranga (Author), Fadel Sayes (Author), Francisca Vicente (Author), Nacho Aguiló (Author), Roland Brosch (Author), Carlos Martín (Author), Jesús Gonzalo-Asensio (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclic (di)nucleotides act as universal second messengers endogenously produced by several pathogens. Specifically, the roles of c-di-AMP in Mycobacterium tuberculosis immunity and virulence have been largely explored, although its contribution to the safety and efficacy of live tuberculosis vaccine...