The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy

• मुख्य लेखकों: Irene Pérez (लेखक), Elena Campos-Pardos (लेखक), Caridad Díaz (लेखक), Santiago Uranga (लेखक), Fadel Sayes (लेखक), Francisca Vicente (लेखक), Nacho Aguiló (लेखक), Roland Brosch (लेखक), Carlos Martín (लेखक), Jesús Gonzalo-Asensio (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2022-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Cyclic (di)nucleotides act as universal second messengers endogenously produced by several pathogens. Specifically, the roles of c-di-AMP in Mycobacterium tuberculosis immunity and virulence have been largely explored, although its contribution to the safety and efficacy of live tuberculosis vaccine...