L-Asparaginase from <i>Penicillium sizovae</i> Produced by a Recombinant <i>Komagataella phaffii</i> Strain

• Main Authors: Marcela Freitas (Author), Paula Souza (Author), Mauricio Homem- (Author), Yris M. Fonseca-Bazzo (Author), Damaris Silveira (Author), Edivaldo X. Ferreira Filho (Author), Adalberto Pessoa Junior (Author), Dipak Sarker (Author), David Timson (Author), João Inácio (Author), Pérola O. Magalhães (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

L-asparaginase is an important enzyme in the pharmaceutical field used as treatment for acute lymphoblastic leukemia due to its ability to hydrolyze L-asparagine, an essential amino acid synthesized by normal cells, but not by neoplastic cells. Adverse effects of L-asparaginase formulations are asso...