Treatment of digital ulcers in systemtic sclerosis with endothelin-1 receptor antagonist (bosentan)

• Asıl Yazarlar: V. Grattagliano (Yazar), F. Iannone (Yazar), A. Chialà (Yazar), M.T. Riccardi (Yazar), M. Covelli (Yazar), G. Lapadula (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: PAGEPress Publications, 2011-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

In systemic sclerosis (SSc) occurrence of recurrent digital ulcers (DU) is cause of pain and functional disability of hands. Treatment with vasodilator agents, such as calcium channel blockers, ACE inhibitors, prostanoids, has not shown to be an effective therapy. There is evidence that endotelin-1...